436799-32-5
- Product Name：5-Bromo-2-trifluoromethylpyridine
- Molecular Formula：C6H3BrF3N
- Purity：99%
- Molecular Weight：225.996
Product Details
Bulk supply high purity 5-Bromo-2-trifluoromethylpyridine 436799-32-5, Paid sample available
- Molecular Formula:C6H3BrF3N
- Molecular Weight:225.996
- Appearance/Colour:white crystal powder
- Vapor Pressure:1.3mmHg at 25°C
- Melting Point:44-46 °C
- Refractive Index:1.471
- Boiling Point:179.1 °C at 760 mmHg
- PKA:-1.80±0.22(Predicted)
- Flash Point:62.1 °C
- PSA：12.89000
- Density:1.707 g/cm3
- LogP:2.86290
2-Trifluoromethyl-5-bromopyridine(Cas 436799-32-5) Usage
InChI:InChI=1/C6H3BrF3N/c7-4-1-2-5(11-3-4)6(8,9)10/h1-3H
436799-32-5 Relevant articles
Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A bottom-Up Approach
Paymode, Dinesh J.,Chang, Le,Chen, Dan,Wang, Binglin,Kashinath, Komirishetty,Gopalsamuthiram, Vijayagopal,McQuade, D. Tyler,Vasudevan,Ahmad, Saeed,Snead, David R.
supporting information, p. 5400 - 5404 (2021/07/26)
MMV390048 (1) is a clinical compound und...
NOVEL COMPOUNDS AS GPR119 AGONISTS
-
Paragraph 0577-0579, (2017/10/26)
The present invention relates to novel c...
NOVEL GPR119 AGONIST COMPOUNDS
-
Paragraph 0445-0447, (2017/10/26)
The present invention relates to novel c...
436799-32-5 Process route
-
-
624-28-2
2,5-dibromopyridine
-
-
680-15-9
2,2-difluoro-2-(fluorosulfonyl)acetate
-
-
436799-32-5
5-bromo-2(trifluoromethyl)pyridine
| Conditions | Yield |
|---|---|
|
With
copper(l) iodide;
In
N,N-dimethyl-formamide;
at 100 ℃;
for 12h;
|
73% |
|
2,5-dibromopyridine;
With
copper(l) iodide;
In
N,N-dimethyl-formamide;
for 0.5h;
2,2-difluoro-2-(fluorosulfonyl)acetate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
|
24.64% |
|
With
copper(l) iodide;
In
N,N-dimethyl-formamide;
at 100 ℃;
for 16h;
Inert atmosphere;
|
66 %Chromat. |
-
-
680-15-9
2,2-difluoro-2-(fluorosulfonyl)acetate
-
-
223463-13-6
2-iodo-5-bromopyridine
-
-
436799-32-5
5-bromo-2(trifluoromethyl)pyridine
| Conditions | Yield |
|---|---|
|
With
copper(l) iodide;
In
1-methyl-pyrrolidin-2-one;
at 80 ℃;
for 16h;
Solvent;
Inert atmosphere;
|
78% |
436799-32-5 Upstream products
-
624-28-2
2,5-dibromopyridine
-
680-15-9
2,2-difluoro-2-(fluorosulfonyl)acetate
-
223463-13-6
2-iodo-5-bromopyridine
436799-32-5 Downstream products
-
216766-13-1
5-methoxy-2-(trifluoromethyl)pyridine
-
867256-50-6
4-(6-trifluoromethyl-pyridin-3-yl)-benzoic acid methyl ester
-
1020329-94-5
tert-butyl 4-(3-(6-(trifluoromethyl)pyridin-3-yloxy)benzylidene)piperidine-1-carboxylate
-
1159998-48-7
benzyl 1-(6-(trifluoromethyl)pyridin-3-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
Relevant Products
-
4-bromo-2-fluorobenzonitrileCAS：105942-08-3
-
2-(3-chloro-5-(trifluoroMethyl)pyridin-2-yl)ethanaMineCAS：658066-44-5
-
2-Bromo-5-trifluoromethylpyridine
CAS：50448-42-1