17282-04-1
- Product Name：2-Chloro-3-Fluoro Pyridine
- Molecular Formula：C5H3ClFN
- Purity：99%
- Molecular Weight：131.537
Product Details
Cost-effective and customizable 2-Chloro-3-Fluoro Pyridine 17282-04-1 for sale
- Molecular Formula:C5H3ClFN
- Molecular Weight:131.537
- Appearance/Colour:Colorless to light yellow liquid
- Vapor Pressure:1.63mmHg at 25°C
- Refractive Index:n20/D 1.509(lit.)
- Boiling Point:151.6 °C at 760 mmHg
- PKA:-0.05±0.10(Predicted)
- Flash Point:45.5 °C
- PSA：12.89000
- Density:1.331 g/cm3
- LogP:1.87410
2-Chloro-3-fluoropyridine(Cas 17282-04-1) Usage
InChI:InChI=1/C8F16O3/c9-1(25)2(10,11)26-7(21,22)8(23,24)27-6(19,20)4(14,15)3(12,13)5(16,17)18
17282-04-1 Relevant articles
Synthesis of 2-Alkylamino-3-fluoropyridines Using Buchwald Conditions
Munson, Peter M.,Thompson, Wayne J.
, p. 759 - 766 (2004)
Synthesis of 2-alkylamino-3-fluoropyridi...
Thorpe–Ingold Effect in Branch-Selective Alkylation of Unactivated Aryl Fluorides
O'Neill, Matthew J.,Riesebeck, Tim,Cornella, Josep
supporting information, p. 9103 - 9107 (2018/07/24)
Presented herein is a general protocol f...
Benzimidazoles that are useful in treating sexual dysfunction
-
, (2008/06/13)
The present invention relates to the use...
Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction
Cowart, Marlon,Latshaw, Steven P.,Bhatia, Pramila,Daanen, Jerome F.,Rohde, Jeffrey,Nelson, Sherry L.,Patel, Meena,Kolasa, Teodozyi,Nakane, Masaki,Uchic, Marie E.,Miller, Loan N.,Terranova, Marc A.,Chang, Renjie,Donnelly-Roberts, Diana L.,Namovic, Marian T.,Hollingsworth, Peter R.,Martino, Brenda R.,Lynch III, James J.,Sullivan, James P.,Hsieh, Gin C.,Moreland, Robert B.,Brioni, Jorge D.,Stewart, Andrew O.
, p. 3853 - 3864 (2007/10/03)
A new class of agents with potential uti...
Benzimidazoles that are useful in treating sexual dysfunction
-
, (2008/06/13)
The present invention relates to the use...
17282-04-1 Process route
-
-
372-47-4
3-Fluoropyridine
-
-
17282-04-1
2-chloro-3-fluoropyridine
| Conditions | Yield |
|---|---|
|
3-Fluoropyridine;
With
1,4-diaza-bicyclo[2.2.2]octane; n-butyllithium;
In
diethyl ether; hexane;
at -65 ℃;
for 1.16667h;
With
hexachloroethane;
In
diethyl ether; hexane;
at -40 ℃;
for 2.25h;
|
63% |
|
3-Fluoropyridine;
With
1,4-diaza-bicyclo[2.2.2]octane; n-butyllithium;
In
diethyl ether; hexane;
at -65 ℃;
for 1.16667h;
With
hexachloroethane;
In
hexanes; diethyl ether;
at -40 ℃;
for 2.25h;
|
63% |
|
With
1,4-diaza-bicyclo[2.2.2]octane; n-butyllithium; hexachloroethane;
In
diethyl ether; hexane;
for 1h;
Inert atmosphere;
Schlenk technique;
|
53% |
|
3-Fluoropyridine;
With
1,4-diaza-bicyclo[2.2.2]octane; n-butyllithium;
In
diethyl ether; hexane;
at -78 ℃;
for 2h;
With
hexachloroethane;
In
tetrahydrofuran; diethyl ether; hexane;
at -78 ℃;
for 1h;
|
52% |
-
![1,4-diaza-bicyclo[2.2.2]octane](/upload/2025/11/0e029fee-1ac9-4079-b7ea-bad33dad1ee6.png)
-
280-57-9,88935-43-7
1,4-diaza-bicyclo[2.2.2]octane
-
-
372-47-4
3-Fluoropyridine
-
-
67-72-1
hexachloroethane
-
-
17282-04-1
2-chloro-3-fluoropyridine
| Conditions | Yield |
|---|---|
|
With
n-butyllithium;
In
tetrahydrofuran; diethyl ether; water;
|
52% |
|
With
n-butyllithium;
In
tetrahydrofuran; diethyl ether; water;
|
52% |
|
With
n-butyllithium;
In
tetrahydrofuran; diethyl ether; water;
|
52% |
|
With
n-butyllithium;
In
tetrahydrofuran; diethyl ether; water;
|
52% |
|
With
n-butyllithium;
In
tetrahydrofuran; diethyl ether; water;
|
52% |
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372-47-4
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-
923012-48-0
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