What is the Benzamidine hydrochloride?

Benzamidine hydrochloride is white to off-white powder, while it's Molecular Formula is C7H8N2 . HCl. white to off-white powder Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 μM, respectively). In addition to its use as a general serine protease inhibitor, benzamidine is used, when immobilized, to purify novel proteases.

What is the CAS number for Benzamidine hydrochloride?

The CAS number of Benzamidine hydrochloride is 1670-14-0.

What is Benzamidine hydrochloride (1670-14-0) used for?

Benzamidine hydrochloride is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.InChI:InChI=1/C7H8N2.ClH.H2O/c8-7(9)6-4-2-1-3-5-6;;/h1-5H,(H3,8,9);1H;1H2

What is the Benzamidine hydrochloride?

Benzamidine hydrochloride is white to off-white powder, while it's Molecular Formula is C7H8N2 . HCl. white to off-white powder Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 μM, respectively). In addition to its use as a general serine protease inhibitor, benzamidine is used, when immobilized, to purify novel proteases.

What is the CAS number for Benzamidine hydrochloride?

The CAS number of Benzamidine hydrochloride is 1670-14-0.

What is Benzamidine hydrochloride (1670-14-0) used for?

Benzamidine hydrochloride is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.InChI:InChI=1/C7H8N2.ClH.H2O/c8-7(9)6-4-2-1-3-5-6;;/h1-5H,(H3,8,9);1H;1H2

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1670-14-0

Product Name：Benzamidine hydrochloride
Molecular Formula：C₇H₈N₂^.HCl
Purity：99%
Molecular Weight：156.615

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Good factory supply good Benzamidine hydrochloride 1670-14-0

Molecular Formula:C7H8N2^.HCl
Molecular Weight:156.615
Appearance/Colour:white to off-white powder
Vapor Pressure:5.63E-05mmHg at 25°C
Melting Point:86-88 °C(lit.)
Boiling Point:208.5 °C at 760 mmHg
Flash Point:79.9 °C
PSA：49.87000
Density:1.09 g/cm³
LogP:2.57270

Benzamidine hydrochloride(Cas 1670-14-0) Usage

Preparation	To a stainless steel rocking autoclave equipped with a stirrer is added 103.0 gm (1.0 mole) of benzonitrile, 214.0 gm (4.0 mole) of ammonium chloride, and 306.0 gm (18.0 mole) of ammonia is introduced by means of a transfer bomb. The reaction mixture is heated at 150°C for 18 hr (pressure: 1300-6500 psig), cooled, and, with appropriate precautions for the safe control of the excess ammonia, is vented to atmospheric pressure. The reaction mixture is extracted with ether to remove approximately 5% unreacted benzonitrile, and then extracted with hot acetonitrile or ethanol to separate the amidine hydrochloride from the unreacted ammonium chloride. Concentration of the latter affords 120.5 gm (77%) of benzamidine hydrochloride, m.p. 161-163°C.
Biological Activity	Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 μM, 21 μM, 20 μM and 110 μM for uPA, trypsin, tryptase and factor Xa, respectively.
Safety Profile	Moderately toxic byintraperitoneal route. When heated to decomposition itemits toxic vapors of NOx, HCl, and Cl-.
in vitro	Benzamidine hydrochloride has weak inhibition for tPA and thrombin, with Kis of 750 μM and 320 μM, respectively.